![]() ![]() Traditionally, researchers have applied sensory stimuli to the rodent paw and tried to infer the animal’s pain state based on the singular readout of whether the animal moved its paw or not. My research focuses on a long-standing question-how does the nervous system encode a soft gentle caress versus a harsh painful stimulation? To accomplish this, the Abdus-Saboor Lab uses neurobiology, computational biology, and mathematics to objectively measure pain-a sensory experience that is inherently subjective. Blutt Presidential Assistant Professor, Biology We hope to use our new molecular tools to unravel the functional basis and causes of neural disorders at a level of detail that has not been accessible to date and empower us to develop novel treatments.Ĭolumbia University (University of Pennsylvania) In the lab, we repurpose proteins found in nature and engineer them to illuminate brain communication. ![]() The Abdelfattah lab is developing novel classes of molecular tools for large-scale functional analysis and manipulation of brain circuits. However, the electrical and chemical signals are not directly visible since there is no natural contrast mechanism that allows us “to see” those signals. ![]() To investigate how brain circuits instantiate fundamental computations underlying behaviors, we need to map their wiring diagrams coupled with functional analysis at cellular resolution to correlate neuron activity with behavior. Carney Assistant Professor of Neuroscienceīrain circuits are dynamic networks of neurons that process information in the form of electrical and chemical signals to form memories and behaviors. ![]()
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